The combinatorics of overlapping genes
نویسندگان
چکیده
منابع مشابه
The combinatorics of overlapping genes.
Overlapping genes exist in all domains of life and are much more abundant than expected upon their first discovery in the late 1970s. Assuming that the reference gene is read in frame +0, an overlapping gene can be encoded in two reading frames in the sense strand, denoted by +1 and +2, and in three reading frames in the opposite strand, denoted by -0, -1, and -2. This motivated numerous resear...
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Overlapping genes are relatively common in DNA and RNA viruses. There are several examples in bacterial and eukaryotic genomes, but, in general, overlapping genes are quite rare in organisms other than viruses. There have been a few reports of overlapping genes in mammalian genomes. The present study identified all of the overlapping loci and overlapping exons in every chromosome of the human g...
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iii Acknowledgments I thank Dr. Giddy Landan for his advice and discussions over many cups of coffee. I thank Dr. Jeff Morris for precious help in matters statistical, philosophical, and theological. I thank Dr. Eran Elhaik and Nicholas Price for enjoyable collaborations. members, for their help and advice. I thank Hoang Hoang and Itala Paz for their tremendous support with numerous cases of co...
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It is believed that 3.2 billion bp of the human genome harbor approximately 35000 protein-coding genes. On average, one could expect one gene per 300000 nucleotides (nt). Although the distribution of the genes in the human genome is not random,it is rather surprising that a large number of genes overlap in the mammalian genomes. Thousands of overlapping genes were recently identified in the hum...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2017
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2016.09.018